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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study which include the recruitment process and consent, adhering and the use of routinely available equipment.

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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be valid and helps reduce bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.

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Legality

Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. The software is available on mobile devices and in a variety of languages. It has established itself as one of the most popular gaming platforms for casinos despite its relatively young age. Wolves is one of its latest releases that is a 5-reel slot machine with a healthy RTP and stunning graphics. Its other notable titles are Wolf Gold and 프라그마틱 슬롯 무료 Chilli Heat.

Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are usually requested by practitioners and policymakers in order to guide their decisions. They are also a good method of determining the causality between an intervention and its outcomes. However, they should not be used to substitute for explanatory trials.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study which includes recruitment, design, implementation of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary-care settings.