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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are typically described as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This kind of heterogeneity is essential for practical trials to be valid and reduces bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners to help guide their decisions. They can also be used to determine the causality of an intervention and its results. However, they should not be used as a substitute for the use of explanation studies.

The concept of pragmatism is controversial, 무료슬롯 프라그마틱 and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary care settings.