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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of study design, including the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and included participants from various geographical areas. This kind of heterogeneity is required for pragmatic trials to be able to prove their validity and helps to reduce the chance of bias in the results. Too much heterogeneity, however could cause issues with the trial design.

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The goal of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually ordered by policymakers and practitioners in order to inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. However, they shouldn't be used as a substitute for explanatory trials.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and 프라그마틱 무료슬롯 Lellouch1 suggested an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a pragmatic trial which includes recruitment, design and delivery of the intervention, as well as the follow-up.

There is an encouraging increase in the number pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to remember, 프라그마틱 이미지 however, that the majority were conducted in primary-care settings.