Nicotine is an addictive chemical. And we must not overlook the fact that the persistent changes are driven by nicotine itself, not other components of tobacco smoke; clearly this argues against the suitability of NRT for smoking cessation in this age group." What appears to alarm Slotkin most is the truth that fetal nicotine harms, including dependency susceptibility, are compounded by adolescent nicotine injury. As Slotkin puts it, "the interplay of prenatal and adolescent nicotine goes past the problem of elevated drug intake.

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