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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described as focusing on practical aspects of design, including recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographical regions. This type of heterogeneity which is vital for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However, too much heterogeneity can result in issues with the design of the trial.

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The goal of pragmatic trials is to mimic real-life scenarios and to achieve maximum validity externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to assess the causality of an intervention and its effects. They should, however, not, be used to replace explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, 프라그마틱 정품확인방법 which validate a physiological or clinical hypothesis, and pragmatic trials, which guide the policy and practice of. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a practical trial, including recruitment, design and delivery of the intervention, and follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.