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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of design that include recruitment and consent, adherence and the use routinely available equipment.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be valid and lessen the chance of bias is also essential. However excessive heterogeneity could lead to issues with the design of the trial.

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Pragmatic Play is known for its top-quality games and for offering an exceptional user experience. Its software is accessible on mobile devices as well as in various languages. Despite its relatively young age it has established itself as a top casino gaming platform. Wolves is one of the most recent releases that is a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are typically commissioned by policy makers and practitioners to inform their decision making. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. They should, however, not be used to replace explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, 프라그마틱 무료체험 which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also suggested the framework for pragmatic trials, 프라그마틱 which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, and follow-up.

There is an encouraging increase in the number pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.