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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on the practical aspects of study design, including the recruitment and consent process, adherence, and the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from various geographical areas. This type of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results, is also necessary. However excessive heterogeneity could lead to issues with the design of the trial.

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Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. Its software is designed to work with mobile devices and is compatible with different languages. It has established itself as one of the leading gaming platforms in the casino industry despite its relative youth. Its latest releases include Wolves, a 5-reel video slot that has a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can also be used to assess the cause-effect relationship of an intervention and its effects. They should, however, not be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a practical trial, including recruitment, design and delivery of the intervention, and monitoring.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, 프라그마틱 홈페이지 이미지 (more..) which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.