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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described as focusing on practical aspects of designing a study which include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is required for practical trials to be valid and also helps to reduce the chance of bias in the results. Too much heterogeneity, however, can cause problems with the trial design.

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The goal of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are usually commissioned by policymakers and practitioners to inform their decisions. They can also be a great way to identify the causality between an intervention and its results. However, they shouldn't be used in lieu for explanation trials.

The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for 프라그마틱 홈페이지 explanations or if they are an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the clinical or physiological hypothesis and pragmatic trials, which inform policy and practice decisions. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial that include recruitment, design and delivery of the intervention, and follow-up.

There is a positive trend in the number of pragmatic trials published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind, however, that the majority were conducted in primary-care settings.