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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often described by their focus on practical aspects of designing a study, including the recruitment process and consent, adhering and the use routinely available equipment.

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Pragmatic is a software company offers a range of casino games on online gambling platforms. Pragmatic's iGaming software is used by top operators as well as land-based casinos. The company provides front-end site design tools, analysis tools and promotions, marketing security payment systems, customer service and bug reporting. The company also provides security, high-quality graphics, gameplay and security.

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RTP

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A pragmatic study that involves various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is vital for pragmatic trials to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity can result in problems with the design of the trial.

Pragmatic Play is also a major player in the live casino market, providing an extensive selection of classic table games such as Blackjack and Roulette in various variations. The live studios of Pragmatic Play in Romania and Malta provide customers with an authentic gaming experience as well as a broad variety of betting options via virtual. The company has also created numerous interactive game shows that make gambling online enjoyable. Some of these shows have live hosts, while others are hosted by celebrities from the industry.

Mobile compatibility

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Legality

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The purpose of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are usually commissioned by policy makers and practitioners to aid in their decision-making. They can also be a great method to determine the causal relationship between an intervention and its outcomes. However, they should not be used to replace the need for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes recruitment, design, delivery of the intervention and follow-up.

There is a positive trend in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.