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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of study design that include the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and 프라그마틱 무료체험 had participants from different geographic areas. This kind of heterogeneity is necessary for practical trials to be valid, and it also helps reduce bias in the results. A high degree of heterogeneity, however could cause issues with the trial design.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum credibility externally. They are typically ordered by policymakers and practitioners to inform their decisions. They can also be used to assess the causality of an intervention with its outcomes. However, 프라그마틱 무료슬롯 they shouldn't be used in lieu for explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and practice decision-making. They also proposed a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a practical trial, including recruitment, design and delivery of the intervention, and follow-up.

There is a positive trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.