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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often characterized as focusing on practical aspects of study design, including the recruitment process and consent, adhering and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from various geographical areas. This type of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically commissioned by practitioners and policy makers to inform their decision making. They can also be used to assess the causality of an intervention and its results. However, they should not be used as a substitute for explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study, including the recruitment, design, and delivery of the intervention, and follow-up.

There is a positive increase in the number pragmatic trials that are published. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, 프라그마틱 추천 it is important to note that the majority of these trials were conducted in primary care settings.