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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are typically characterized by a focus on the practical aspects of study design, including recruitment and consent in adherence, as well as the use of standard equipment.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity can result in problems with the trial design.

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The goal of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually commissioned by policymakers and practitioners to guide their decisions. They can also be used to determine the causal relationship between an intervention and its effects. However, they should not be used to replace explanation studies.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes the recruitment, design, and delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs), yielded 34 articles, 프라그마틱 플레이 as shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to keep in mind that the majority were conducted in primary care settings.