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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically focused on the practical aspects of the study design, such as the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from various geographical areas. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are typically ordered by policymakers and practitioners in order to guide their decisions. They also provide a useful method of determining the causal relationship between the intervention and its effects. However, they should not be used in lieu for explanation studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for 프라그마틱 무료체험 메타 pragmatic trials.2 This tool tried to define the elements of a pragmatic study that includes recruitment, design, delivery of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of studies were conducted in primary care settings.