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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of study design, such as the recruitment and consent process, adherence, and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, 프라그마틱 슬롯버프 which used different investigators and included participants from different geographical regions. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity, and it also helps reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.

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The goal of pragmatic trials is to replicate real-life scenarios and to achieve maximum validity externally. They are usually commissioned by practitioners and policy makers to guide their decision-making. They also provide a useful method of determining the causal relationship between an intervention and its results. However, they should not, be used to replace explanatory studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm a physiological or clinical hypothesis and pragmatic trials, which guide the policy and practice of. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.

There is a growing increase in the number pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.