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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described by their focus on practical aspects of design, including the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be valid and also helps to reduce the chance of bias in the results. However excessive heterogeneity could cause issues with the design of the trial.

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The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. They are typically requested by practitioners and policymakers to inform their decisions. They are also a good method of determining the causal relationship between an intervention and its outcomes. They should not, however, 프라그마틱 플레이 추천 (brewwiki.win official website) be used to replace the need for explanation studies.

The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic research study that includes recruitment, design, delivery of the intervention and its follow-up.

There is a growing increase in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of studies were conducted in primary-care settings.