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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on practical aspects of the research design, like the recruitment and consent process in adherence, as well as the use of routinely available equipment.

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A pragmatic trial that uses various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can result in problems with the trial design.

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Pragmatic Play is known for its top-notch games, and for providing a superior user experience. Its software is designed to work with mobile devices and 슬롯 supports multiple languages. Despite its infancy it has already established itself as a top gaming platform for casinos. The latest releases include Wolves which is a five-reel video slot with a healthful RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They also provide a useful method of determining the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for explanatory studies.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis and pragmatic trials, which inform the practice and policy decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool attempted to define the features of a pragmatic study that include the recruitment process, the design and implementation of the intervention, as well as the follow-up.

The number of pragmatic trials is growing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.