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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of study design which include the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from various geographical areas. This type of heterogeneity, 프라그마틱 무료게임 that is crucial for a pragmatic trial to be reliable and to reduce bias in the results, 프라그마틱 슬롯 사이트 (Www.Google.bs) is also necessary. A high degree of heterogeneity, however can result in problems with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. Usually, they are ordered by policymakers and practitioners to guide their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. They should not, however be used to replace explanatory studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they are an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a pragmatic trial, including recruitment, design and delivery of the intervention, as well as the follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.