Polymorphism is significantly associated with CHD. R353Q polymorphism showed trend for association with CHD 2-(2,4-Dichloro-5-fluorophenyl)oxirane in Asian people but probably not in Europeans. Lack of association was found for HVR4 polymorphism. Further studies are needed to confirm the association, especially for -323Ins10 polymorphisms.Additional materialAdditional file 1: Characteristics of the 39 eligible studies included in meta-analysis. A table summarized the detailed characteristics of each study included in the meta-analysis (First authors, published year, and mean age, percentage of men and genotype data in case control groups, etc.). a 323 in the 5' promoter region, (10-bp insertion in the promoter region (5'FVII)), where allele A1 corresponds to the absence of the decamer (0) and allele A2 to its insertion(10). b NS = not specified, M = matched. c Study for Chinese Hui population. d Study for Chinese Han populationAbbreviations CHD: coronary heart disease; CI: confidence interval; FVII: coagulation factor VII; HuGE: human genome epidemiology; HWE: hardy-Weinberg equilibrium; MI: myocardial infarction; OR: odds ratio. Acknowledgements This work was supported by National Basic meo.v19.25901 Research Program of China (Grant No. 2011CB503901), National Natural Science Foundation of China (Grant No. 30930047).Mo et al. BMC Medical Genetics 2011, 12:107 http://www.biomedcentral.com/1471-2350/12/Page 8 of15. Tamaki S, Iwai N, Nakamura Y, Tsujita Y, Kinoshita M: Variation of the factor VII gene and ischemic heart disease in Japanese subjects. Coron Artery Dis 1999, 10:601-606. 16. Ardissino D, Mannucci PM, Merlini PA, Duca F, Fetiveau R, Tagliabue L, Tubaro M, Galvani M, Ottani F, Ferrario M, Corral J, Margaglione M: Prothrombotic genetic risk factors in young survivors of myocardial infarction. Blood 1999, 94:46-51. 17. Feng D, Tofler GH, Larson MG, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/9638577 O'Donnell CJ, Lipinska I, Schmitz C, Sutherland 1-(Cyclopropylsulfonyl)-1,4-diazepane PA, Johnstone MT, Muller JE, D'Agostino RB, Levy D, Lindpaintner K: Factor VII gene polymorphism, Factor VII levels, and prevalent cardiovascular disease: the Framingham Heart Study. Arterioscler Thromb Vasc Biol 2000, 20:593-600. 18. Lievers KJ, Mennen LI, Rattink AP, Zwinderman AH, Jukema JW, Schouten EG, de Maat MP: The -323Ins10 polymorphism for Factor VII is not associated with coronary atherosclerosis in symptomatic men. The REGRESS study group. Thromb Res 2000, 97:275-280. 19. Pollak ES, Hung HL, Godin W, Overton GC, High KA: Functional characterisation of the human factor VII 59-flanking region. J PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/9544797 Biol Chem 1996, 271:1738-1747. 20. Wu AH, Tsongalis GJ: Correlation of polymorphisms to coagulation and biochemical risk factors for cardiovascular diseases. Am J Cardiol 2001, 87(12):1361-1366. 21. Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, Danesh J: Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet 2006, 367(9511):651-658. 22. Higgins JP, Thompson SG, Deeks JJ, Altman DG: Measuring inconsistency in meta-analyses. BMJ 2003, 327:557-560. 23. Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315(7109):629-634. 24. DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177-188. 25. Ioannidis JP, Trikalinos TA: Early extreme contradictory estimates may appear in published research: the Proteus phenomenon in molecular genetics research and randomized trials. J Clin Epidemiol 2005, 58:543-549. 26. Huang H, Jia S, Chen.